Diagnosing Ethanol Toxicity

Role of estradiol in reducing ethanol toxicity.

Ethanol toxicity differs depending on the time of day

Ethanol is one of the most commonly abused drugs and consequently its toxic and psychoactive effect has been widely investigated, although little is known about the time-dependent effects of this drug. In the present research zebrafish was used to assess daily rhythms in ethanol toxicity and behavioural effects, as well as the temporal pattern of expression of key genes involved in ethanol deto...

Ethanol Toxicity in the Brain: Alteration of Astroglial Cell Function

Ethanol consumption has for a long time been associated with brain damage. Experimental studies and necropsy examinations of chronic alcoholics have shown a variety of structural and functional alterations in the neurons as well as in the glial cells. Such alterations are seen also in children with the alcoholic foetal syndrome. Ethanol is known to be a teratogen. Its abusage can result as dysf...

Exogenous Nucleotides Antagonize the Developmental Toxicity of Ethanol In Vitro

The objective of this study was to assess whether nucleotides supplementation in vitro could suppress ethanol-induced developmental toxicity in mouse. The models of whole embryo culture (WEC) and midbrain (MB) cell micromass culture were used in this study. In WEC system, exposure to 4.0 mg/mL ethanol for 48 h yielded various developmental malformations of the mice embryos. Nucleotides suppleme...

Specific Conditions for Resveratrol Neuroprotection against Ethanol-Induced Toxicity

Aims. 3,5,4'-Trihydroxy-trans-stilbene, a natural polyphenolic compound present in wine and grapes and better known as resveratrol, has free radical scavenging properties and is a potent protector against oxidative stress induced by alcohol metabolism. Today, the mechanism by which ethanol exerts its toxicity is still not well understood, but it is generally considered that free radical generat...